Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome

NCT00445744 · clinicaltrials.gov ↗

NA

Phase

COMPLETED

Status

52

Enrollment

OTHER

Sponsor class

Conditions

Adult Acute Myeloid Leukemia in Remission
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Adult Acute Myeloid Leukemia With Del(5q)
Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
Childhood Acute Myeloid Leukemia in Remission
Childhood Myelodysplastic Syndromes
de Novo Myelodysplastic Syndromes
Essential Thrombocythemia
Myelodysplastic Syndrome With Isolated Del(5q)
Polycythemia Vera
Previously Treated Myelodysplastic Syndromes
Primary Myelofibrosis
Recurrent Adult Acute Myeloid Leukemia
Recurrent Childhood Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia
Secondary Myelodysplastic Syndromes
Secondary Myelofibrosis
Untreated Adult Acute Myeloid Leukemia
Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

Interventions

DRUG: cyclophosphamide
DRUG: busulfan
DRUG: tacrolimus
DRUG: methotrexate
GENETIC: cytogenetic analysis
OTHER: flow cytometry
OTHER: pharmacological study
OTHER: pharmacogenomic studies
PROCEDURE: peripheral blood stem cell transplantation
PROCEDURE: allogeneic hematopoietic stem cell transplantation

Sponsor

Fred Hutchinson Cancer Center

Collaborators

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