Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2

NCT00810303 · clinicaltrials.gov ↗

PHASE1

Phase

COMPLETED

Status

12

Enrollment

OTHER

Sponsor class

Conditions

Pharmacokinetics
Drug Interactions
Pharmacodynamics
Intestinal Transporter Expression

Interventions

DRUG: Ezetrol (ezetimibe) multiple dose
DRUG: Ezetrol (ezetimibe) multiple dose and Sustiva (efavirenz) single dose
DRUG: Ezetrol (ezetimibe) and Sustiva (efavirenz) multiple dose
DRUG: Sustiva (efavirenz) single dose

Sponsor

University Medicine Greifswald