Trametinib or Combination Chemotherapy in Treating Patients With Refractory or Advanced Biliary or Gallbladder Cancer or That Cannot Be Removed by Surgery

NCT02042443 · clinicaltrials.gov ↗

PHASE2

Phase

COMPLETED

Status

53

Enrollment

NIH

Sponsor class

Conditions

Adult Cholangiocarcinoma
Advanced Adult Hepatocellular Carcinoma
BCLC Stage C Adult Hepatocellular Carcinoma
BCLC Stage D Adult Hepatocellular Carcinoma
Hilar Cholangiocarcinoma
Localized Non-Resectable Adult Liver Carcinoma
Recurrent Adult Liver Carcinoma
Recurrent Childhood Liver Cancer
Recurrent Extrahepatic Bile Duct Carcinoma
Recurrent Gallbladder Carcinoma
Stage II Gallbladder Cancer
Stage III Childhood Hepatocellular Carcinoma
Stage IIIA Gallbladder Cancer
Stage IIIB Gallbladder Cancer
Stage IV Childhood Hepatocellular Carcinoma
Stage IV Distal Bile Duct Cancer
Stage IVA Gallbladder Cancer
Stage IVB Gallbladder Cancer
Unresectable Extrahepatic Bile Duct Carcinoma

Interventions

DRUG: Capecitabine
DRUG: Fluorouracil
OTHER: Laboratory Biomarker Analysis
DRUG: Leucovorin Calcium
DRUG: Trametinib

Sponsor

National Cancer Institute (NCI)