Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid Neoplasms
Conditions
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells
- Chronic Myelomonocytic Leukemia-2
- High Grade Malignant Neoplasm
- Myelodysplastic Syndrome
- Myelodysplastic Syndrome With Excess Blasts-2
- Myeloid Neoplasm
- Previously Treated Myelodysplastic Syndrome
- Recurrent Acute Myeloid Leukemia
- Refractory Acute Myeloid Leukemia
Interventions
- DRUG: Cladribine
- DRUG: Cyclosporine
- DRUG: Cytarabine
- BIOLOGICAL: Filgrastim
- DRUG: Fludarabine Phosphate
- PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
- OTHER: Laboratory Biomarker Analysis
- DRUG: Melphalan
- DRUG: Mitoxantrone Hydrochloride
- DRUG: Mycophenolate Mofetil
- OTHER: Questionnaire Administration
- DRUG: Sirolimus
- RADIATION: Total-Body Irradiation
- DRUG: Melphalan Hydrochloride
Sponsor
University of Washington
Collaborators