Obinutuzumab With or Without Umbralisib, Lenalidomide, or Combination Chemotherapy in Treating Patients With Relapsed or Refractory Grade I-IIIa Follicular Lymphoma

NCT03269669 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

73

Enrollment

NIH

Sponsor class

Conditions

Grade 1 Follicular Lymphoma
Grade 2 Follicular Lymphoma
Grade 3a Follicular Lymphoma
Recurrent Follicular Lymphoma
Refractory Follicular Lymphoma

Interventions

DRUG: Bendamustine Hydrochloride
PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
DRUG: Cyclophosphamide
DRUG: Doxorubicin Hydrochloride
PROCEDURE: Echocardiography Test
DRUG: Lenalidomide
PROCEDURE: Multigated Acquisition Scan
BIOLOGICAL: Obinutuzumab
PROCEDURE: Positron Emission Tomography
DRUG: Prednisone
DRUG: Umbralisib
DRUG: Vincristine Sulfate

Sponsor

National Cancer Institute (NCI)