Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant
Conditions
- Acute Biphenotypic Leukemia
- Acute Leukemia
- Acute Leukemia of Ambiguous Lineage
- Acute Lymphoblastic Leukemia
- Acute Undifferentiated Leukemia
- Allogeneic Hematopoietic Stem Cell Transplantation Recipient
- Blastic Plasmacytoid Dendritic Cell Neoplasm
- Blasts Under 25 Percent of Bone Marrow Nucleated Cells
- Blasts Under 5 Percent of Bone Marrow Nucleated Cells
- Mixed Phenotype Acute Leukemia
- Myelodysplastic Syndrome With Excess Blasts-1
- Myelodysplastic Syndrome/Acute Myeloid Leukemia
- Burkitt Leukemia
- Chronic Monocytic Leukemia
- Lymphoblastic Lymphoma
- Mast Cell Leukemia
- Myeloproliferative Neoplasm
Interventions
- RADIATION: Total-Body Irradiation
- DRUG: Thiotepa
- DRUG: Fludarabine
- DRUG: Cyclophosphamide
- DRUG: Busulfan
- PROCEDURE: Allogeneic Bone Marrow Transplantation
- DRUG: Tacrolimus
- DRUG: Methotrexate
- PROCEDURE: Naive T Cell-Depleted Hematopoietic Stem Cell Transplantation
- PROCEDURE: Echocardiography
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Bone Marrow Aspiration
- PROCEDURE: Bone Marrow Biopsy
Sponsor
Fred Hutchinson Cancer Center
Collaborators