Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study
ACTIVE_NOT_RECRUITING
Status
Conditions
- Clear Cell Renal Cell Carcinoma
- Metastatic Malignant Neoplasm in the Bone
- Metastatic Malignant Neoplasm in the Lymph Nodes
- Metastatic Malignant Neoplasm in the Soft Tissue
- Metastatic Malignant Neoplasm in the Viscera
- Rhabdoid Tumor of the Kidney
- Sarcomatoid Renal Cell Carcinoma
- Stage III Renal Cell Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8
Interventions
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Bone Scan
- DRUG: Cabozantinib
- PROCEDURE: Computed Tomography
- BIOLOGICAL: Ipilimumab
- PROCEDURE: Magnetic Resonance Imaging
- BIOLOGICAL: Nivolumab
- OTHER: Quality-of-Life Assessment
- OTHER: Questionnaire Administration
Sponsor
National Cancer Institute (NCI)