Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
Conditions
- Bladder Adenocarcinoma
- Bladder Clear Cell Adenocarcinoma
- Bladder Mixed Adenocarcinoma
- Bladder Neuroendocrine Carcinoma
- Bladder Small Cell Neuroendocrine Carcinoma
- Bladder Squamous Cell Carcinoma
- Chromophobe Renal Cell Carcinoma
- Collecting Duct Carcinoma
- Invasive Bladder Giant Cell Urothelial Carcinoma
- Invasive Bladder Lymphoepithelioma-Like Carcinoma
- Invasive Bladder Nested Urothelial Carcinoma
- Invasive Bladder Plasmacytoid Urothelial Carcinoma
- Invasive Bladder Sarcomatoid Urothelial Carcinoma
- Invasive Bladder Urothelial Carcinoma
- Kidney Medullary Carcinoma
- Large Cell Neuroendocrine Carcinoma
- Malignant Testicular Leydig Cell Tumor
- Malignant Testicular Sertoli Cell Tumor
- Metastatic Bladder Carcinoma
- Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma
- Metastatic Bladder Giant Cell Urothelial Carcinoma
- Metastatic Bladder Large Cell Neuroendocrine Carcinoma
- Metastatic Bladder Lipid-Rich Urothelial Carcinoma
- Metastatic Bladder Micropapillary Urothelial Carcinoma
- Metastatic Bladder Plasmacytoid Urothelial Carcinoma
- Metastatic Bladder Sarcomatoid Urothelial Carcinoma
- Metastatic Bladder Small Cell Neuroendocrine Carcinoma
- Metastatic Bladder Squamous Cell Carcinoma
- Metastatic Chromophobe Renal Cell Carcinoma
- Metastatic Kidney Medullary Carcinoma
- Metastatic Malignant Genitourinary System Neoplasm
- Metastatic Papillary Renal Cell Carcinoma
- Metastatic Penile Carcinoma
- Metastatic Prostate Small Cell Neuroendocrine Carcinoma
- Metastatic Sarcomatoid Renal Cell Carcinoma
- Metastatic Urethral Carcinoma
- Papillary Renal Cell Carcinoma
- Sarcomatoid Renal Cell Carcinoma
- Stage IV Bladder Cancer AJCC v8
- Stage IV Penile Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8
- Stage IV Urethral Cancer AJCC v8
- Stage IVB Prostate Cancer AJCC v8
- Urachal Adenocarcinoma
- Urethral Clear Cell Adenocarcinoma
Interventions
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Bone Scan
- DRUG: Cabozantinib S-malate
- PROCEDURE: Computed Tomography
- PROCEDURE: Echocardiography Test
- BIOLOGICAL: Ipilimumab
- PROCEDURE: Magnetic Resonance Imaging
- BIOLOGICAL: Nivolumab
- PROCEDURE: Positron Emission Tomography
Sponsor
National Cancer Institute (NCI)