Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

NCT03919071 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

58

Enrollment

NIH

Sponsor class

Conditions

Anaplastic Astrocytoma
Anaplastic Astrocytoma, Not Otherwise Specified
Anaplastic Ganglioglioma
Anaplastic Pleomorphic Xanthoastrocytoma
Glioblastoma
Malignant Glioma
WHO Grade 3 Glioma
WHO Grade 4 Glioma

Interventions

PROCEDURE: Biospecimen Collection
DRUG: Dabrafenib Mesylate
PROCEDURE: Lumbar Puncture
PROCEDURE: Magnetic Resonance Imaging
RADIATION: Radiation Therapy
DRUG: Trametinib Dimethyl Sulfoxide

Sponsor

National Cancer Institute (NCI)