Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects

Stopped PI choice; poor accrual

Conditions

• ATM Gene Mutation
• BRCA1 Gene Mutation
• BRCA2 Gene Mutation
• BRIP1 Gene Mutation
• CDK12 Gene Mutation
• CHEK1 Gene Mutation
• CHEK2 Gene Mutation
• DNA Damage Response Gene Mutation
• DNA Repair Gene Mutation
• FANCA Gene Mutation
• FANCD2 Gene Mutation
• FANCL Gene Mutation
• GEN1 Gene Mutation
• NBN Gene Mutation
• Prostate Carcinoma
• RAD51 Gene Mutation
• RAD51C Gene Mutation

Interventions

• DRUG: Niraparib
• DRUG: Niraparib Tosylate Monohydrate
• PROCEDURE: Radical Prostatectomy

Sponsor

University of California, Davis

Collaborators

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