# Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed

> **NCT04132336** · PHASE2 · COMPLETED · sponsor: **Bayer** · enrollment: 193 (actual)

## Conditions studied

- Pain, Postoperative

## Interventions

- **DRUG:** Naproxen sodium/Caffeine (BAY2880376)
- **DRUG:** Naproxen sodium (Aleve)
- **DRUG:** Caffeine
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT04132336
- **Lead sponsor:** Bayer
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-11-12
- **Primary completion:** 2020-03-02
- **Final completion:** 2020-03-03
- **Target enrollment:** 193 (ACTUAL)
- **Last updated:** 2021-09-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04132336

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04132336, "Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed". Retrieved via MORVS 2026-10-12 from https://api.morvs.ai/clinical/NCT04132336. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*