# CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)

> **NCT04151342** · — · RECRUITING · sponsor: **University Health Network, Toronto** · enrollment: 5500 (estimated)

## Conditions studied

- Cancer
- Malignancies Multiple
- Malignant Solid Tumor
- Cancer, Therapy-Related
- Molecular Sequence Variation
- Genetic Alteration
- Gene Fusion
- Receptor Tyrosine Kinase Gene Mutation
- RTK Family Gene Mutation
- Ras (Kras or Nras) Gene Mutation

## Interventions

- **DRUG:** Cancer treatment with tyrosine kinase inhibitors (TKIs) or other molecularly targeted therapeutic agents.
- **OTHER:** Patient-reported outcomes (PROs)

## Key facts

- **NCT ID:** NCT04151342
- **Lead sponsor:** University Health Network, Toronto
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2020-01-17
- **Primary completion:** 2029-12
- **Final completion:** 2029-12
- **Target enrollment:** 5500 (ESTIMATED)
- **Last updated:** 2025-12-03

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04151342

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04151342, "CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)". Retrieved via MORVS 2026-10-18 from https://api.morvs.ai/clinical/NCT04151342. Licensed CC0.

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