Testing the Addition of Targeted Radiation Therapy to Surgery and the Usual Chemotherapy Treatment (Pemetrexed and Cisplatin [or Carboplatin]) for Stage I-IIIA Malignant Pleural Mesothelioma

NCT04158141 · clinicaltrials.gov ↗

PHASE3

Phase

TERMINATED

Status

16

Enrollment

OTHER

Sponsor class

Stopped Permanent Administrative Closure

Conditions

Pleural Biphasic Mesothelioma
Pleural Epithelioid Mesothelioma
Stage I Pleural Malignant Mesothelioma AJCC v8
Stage IA Pleural Malignant Mesothelioma AJCC v8
Stage IB Pleural Malignant Mesothelioma AJCC v8
Stage II Pleural Malignant Mesothelioma AJCC v8
Stage IIIA Pleural Malignant Mesothelioma AJCC v8

Interventions

DRUG: Carboplatin
DRUG: Cisplatin
PROCEDURE: Decortication
RADIATION: Intensity-Modulated Radiation Therapy
DRUG: Pemetrexed
DRUG: Pemetrexed Disodium
RADIATION: Pencil beam scanning proton therapy
PROCEDURE: Pleurectomy

Sponsor

NRG Oncology

Collaborators

National Cancer Institute (NCI)