A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE Trial

NCT04216290 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

95

Enrollment

NIH

Sponsor class

Conditions

Bladder Urothelial Carcinoma
Stage III Bladder Cancer AJCC v8

Interventions

PROCEDURE: Biopsy of Bladder
PROCEDURE: Biospecimen Collection
DRUG: Cisplatin
PROCEDURE: Computed Tomography
PROCEDURE: Cystoscopy
BIOLOGICAL: Durvalumab
DRUG: Fluorouracil
DRUG: Gemcitabine Hydrochloride
PROCEDURE: Magnetic Resonance Imaging
DRUG: Mitomycin
OTHER: Patient Observation
RADIATION: Radiation Therapy

Sponsor

National Cancer Institute (NCI)