Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals

PHASE2

Phase

TERMINATED

Status

Enrollment

NIH

Sponsor class

Stopped Opening of Arm 2 was dependent upon assessment of DTG pharmacokinetics (PK) data from participants in Arm 1. Arm 1 is complete and results are reported. Arm 2 was not conducted based on the Arm 1 PK assessment.

Conditions

HIV Infection
LTBI

Interventions

DRUG: Dolutegravir (DTG)
DRUG: Isoniazid (INH)
DRUG: Rifapentine (RPT)
DRUG: Antiretroviral Therapy (ART)
DIETARY_SUPPLEMENT: Pyridoxine (Vitamin B6)

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Collaborators

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