Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

NCT04530565 · clinicaltrials.gov ↗

PHASE3

Phase

ACTIVE_NOT_RECRUITING

Status

348

Enrollment

NIH

Sponsor class

Conditions

B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

Interventions

PROCEDURE: Biospecimen Collection
BIOLOGICAL: Blinatumomab
PROCEDURE: Bone Marrow Aspiration and Biopsy
DRUG: Cyclophosphamide
DRUG: Cytarabine
DRUG: Dasatinib
DRUG: Dexamethasone
DRUG: Doxorubicin Hydrochloride
PROCEDURE: Echocardiography Test
PROCEDURE: Electrocardiography
PROCEDURE: Lumbar Puncture
DRUG: Mesna
DRUG: Methotrexate
PROCEDURE: Multigated Acquisition Scan
DRUG: Ponatinib Hydrochloride
DRUG: Prednisone
DRUG: Vincristine Sulfate

Sponsor

National Cancer Institute (NCI)