Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, The GD2-CAR PERSIST Trial

NCT04539366 · clinicaltrials.gov ↗

PHASE1

Phase

SUSPENDED

Status

67

Enrollment

NIH

Sponsor class

Stopped Other - review of safety data

Conditions

Recurrent Childhood Neuroblastoma
Recurrent Childhood Osteosarcoma
Recurrent Neuroblastoma
Recurrent Osteosarcoma
Refractory Childhood Neuroblastoma
Refractory Childhood Osteosarcoma
Refractory Neuroblastoma
Refractory Osteosarcoma

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy
DRUG: Cyclophosphamide
PROCEDURE: Echocardiography Test
DRUG: Fludarabine Phosphate
BIOLOGICAL: GD2-CAR-expressing Autologous T-lymphocytes
PROCEDURE: Imaging Procedure
PROCEDURE: Magnetic Resonance Imaging of the Heart
PROCEDURE: Multigated Acquisition Scan
OTHER: Questionnaire Administration

Sponsor

National Cancer Institute (NCI)