Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

NCT04628767 · clinicaltrials.gov ↗

PHASE2,PHASE3

Phase

RECRUITING

Status

249

Enrollment

NIH

Sponsor class

Conditions

Renal Pelvis and Ureter Urothelial Carcinoma

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
DRUG: Cisplatin
PROCEDURE: Computed Tomography
DRUG: Doxorubicin Hydrochloride
BIOLOGICAL: Durvalumab
DRUG: Gemcitabine Hydrochloride
PROCEDURE: Magnetic Resonance Imaging
DRUG: Methotrexate
BIOLOGICAL: Pegfilgrastim
PROCEDURE: Therapeutic Conventional Surgery
DRUG: Vinblastine Sulfate

Sponsor

National Cancer Institute (NCI)