Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

NCT04671667 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

188

Enrollment

NIH

Sponsor class

Conditions

Recurrent Head and Neck Squamous Cell Carcinoma
Recurrent Hypopharyngeal Squamous Cell Carcinoma
Recurrent Laryngeal Squamous Cell Carcinoma
Recurrent Oral Cavity Squamous Cell Carcinoma
Recurrent Oropharyngeal Squamous Cell Carcinoma

Interventions

DRUG: Carboplatin
DRUG: Cisplatin
PROCEDURE: Computed Tomography
RADIATION: Intensity-Modulated Radiation Therapy
PROCEDURE: Magnetic Resonance Imaging
BIOLOGICAL: Pembrolizumab
RADIATION: Proton Beam Radiation Therapy

Sponsor

National Cancer Institute (NCI)