Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial
ACTIVE_NOT_RECRUITING
Status
Conditions
- Advanced Breast Carcinoma
- Advanced Colon Carcinoma
- Advanced Colorectal Carcinoma
- Advanced Endometrial Carcinoma
- Advanced Gastric Carcinoma
- Advanced Gastroesophageal Junction Adenocarcinoma
- Advanced Malignant Solid Neoplasm
- Advanced Salivary Gland Carcinoma
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage IV Breast Cancer AJCC v8
- Clinical Stage III Gastric Cancer AJCC v8
- Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
- Clinical Stage IV Gastric Cancer AJCC v8
- Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
- HER2-Positive Breast Carcinoma
- Malignant Hepatobiliary Neoplasm
- Metastatic Breast Carcinoma
- Metastatic Colon Carcinoma
- Metastatic Colorectal Carcinoma
- Metastatic Endometrial Carcinoma
- Metastatic Gastric Carcinoma
- Metastatic Gastroesophageal Junction Adenocarcinoma
- Metastatic Malignant Solid Neoplasm
- Metastatic Salivary Gland Carcinoma
- Stage III Colon Cancer AJCC v8
- Stage III Colorectal Cancer AJCC v8
- Stage III Major Salivary Gland Cancer AJCC v8
- Stage III Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
- Stage IV Colon Cancer AJCC v8
- Stage IV Colorectal Cancer AJCC v8
- Stage IV Major Salivary Gland Cancer AJCC v8
- Stage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
- Unresectable Breast Carcinoma
- Unresectable Colon Carcinoma
- Unresectable Colorectal Carcinoma
- Unresectable Endometrial Carcinoma
- Unresectable Gastric Carcinoma
- Unresectable Gastroesophageal Junction Adenocarcinoma
- Unresectable Malignant Solid Neoplasm
- Unresectable Salivary Gland Carcinoma
Interventions
- PROCEDURE: Biopsy Procedure
- PROCEDURE: Biospecimen Collection
- DRUG: Ceralasertib
- PROCEDURE: Computed Tomography
- PROCEDURE: Echocardiography Test
- PROCEDURE: Multigated Acquisition Scan
- PROCEDURE: Positron Emission Tomography
- BIOLOGICAL: Trastuzumab Deruxtecan
Sponsor
National Cancer Institute (NCI)