Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma

NCT04759586 · clinicaltrials.gov ↗

PHASE3

Phase

ACTIVE_NOT_RECRUITING

Status

244

Enrollment

NIH

Sponsor class

Conditions

Primary Mediastinal Large B-Cell Lymphoma

Interventions

PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy
PROCEDURE: Computed Tomography
DRUG: Cyclophosphamide
DRUG: Doxorubicin Hydrochloride
PROCEDURE: Echocardiography Test
DRUG: Etoposide Phosphate
BIOLOGICAL: Filgrastim
PROCEDURE: Lumbar Puncture
BIOLOGICAL: Nivolumab
BIOLOGICAL: Pegfilgrastim
PROCEDURE: Positron Emission Tomography
DRUG: Prednisolone
DRUG: Prednisone
RADIATION: Radiation Therapy
BIOLOGICAL: Rituximab
BIOLOGICAL: Rituximab and Hyaluronidase Human
DRUG: Vincristine Sulfate

Sponsor

National Cancer Institute (NCI)