Testing CC-486 (Oral Azacitidine) Plus the Standard Drug Therapy in Patients 75 Years or Older With Newly Diagnosed Diffuse Large B Cell Lymphoma

Conditions

• Ann Arbor Stage III Diffuse Large B-Cell Lymphoma
• Ann Arbor Stage IIX (Bulky) Diffuse Large B-Cell Lymphoma
• Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma
• Diffuse Large B-Cell Lymphoma Activated B-Cell Type
• Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation
• Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
• Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
• EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
• Grade 3b Follicular Lymphoma
• HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
• High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements
• High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
• High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements
• High Grade B-Cell Lymphoma, Not Otherwise Specified
• Intravascular Large B-Cell Lymphoma
• Lymphoplasmacytic Lymphoma
• Nodular Lymphocyte Predominant B-Cell Lymphoma
• Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
• T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
• Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma
• Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

Interventions

• PROCEDURE: Biospecimen Collection
• PROCEDURE: Computed Tomography
• DRUG: Cyclophosphamide
• DRUG: Doxorubicin Hydrochloride
• PROCEDURE: Echocardiography Test
• PROCEDURE: Multigated Acquisition Scan
• DRUG: Oral Azacitidine
• PROCEDURE: Positron Emission Tomography
• DRUG: Prednisone
• OTHER: Questionnaire Administration
• BIOLOGICAL: Rituximab
• BIOLOGICAL: Rituximab and Hyaluronidase Human
• DRUG: Vincristine Sulfate

Sponsor

National Cancer Institute (NCI)