Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis

NCT04847453 · clinicaltrials.gov ↗

PHASE1

Phase

ACTIVE_NOT_RECRUITING

Status

24

Enrollment

NIH

Sponsor class

Conditions

Recurrent AL Amyloidosis
Refractory AL Amyloidosis

Interventions

PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration and Biopsy
PROCEDURE: Computed Tomography
DRUG: Dexamethasone
PROCEDURE: Echocardiography Test
DRUG: Ixazomib Citrate
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Positron Emission Tomography
PROCEDURE: Transabdominal Ultrasound
DRUG: Venetoclax
PROCEDURE: X-Ray Imaging

Sponsor

National Cancer Institute (NCI)