Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

NCT04929028 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

40

Enrollment

NIH

Sponsor class

Conditions

AIDS-Related Anal Carcinoma
Anal Margin Squamous Cell Carcinoma
Anal Non-Keratinizing Squamous Cell Carcinoma
Anal Squamous Cell Carcinoma
HIV Infection
Rectal Squamous Cell Carcinoma
Stage II Rectal Cancer AJCC v8
Stage IIB Anal Cancer AJCC v8
Stage III Anal Cancer AJCC v8
Stage III Rectal Cancer AJCC v8

Interventions

PROCEDURE: Anoscopy
PROCEDURE: Biospecimen Collection
DRUG: Capecitabine
PROCEDURE: Colonoscopy
PROCEDURE: Computed Tomography
PROCEDURE: Digital Rectal Examination
PROCEDURE: Echocardiography Test
OTHER: Fludeoxyglucose F-18
DRUG: Fluorouracil
RADIATION: Intensity-Modulated Radiation Therapy
PROCEDURE: Lymph Node Biopsy
PROCEDURE: Magnetic Resonance Imaging
DRUG: Mitomycin
BIOLOGICAL: Nivolumab
PROCEDURE: Positron Emission Tomography
PROCEDURE: Proctoscopy
OTHER: Questionnaire Administration
PROCEDURE: Sigmoidoscopy

Sponsor

National Cancer Institute (NCI)