# Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

> **NCT04929041** · PHASE2,PHASE3 · SUSPENDED · sponsor: **National Cancer Institute (NCI)** · enrollment: 427 (estimated)

## Conditions studied

- Lung Adenocarcinoma
- Lung Adenosquamous Carcinoma
- Lung Non-Small Cell Carcinoma
- Stage IIIB Lung Cancer AJCC v8
- Stage IIIC Lung Cancer AJCC v8
- Stage IV Lung Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Echocardiography Test
- **BIOLOGICAL:** Ipilimumab
- **PROCEDURE:** Magnetic Resonance Imaging
- **BIOLOGICAL:** Nivolumab
- **PROCEDURE:** Positron Emission Tomography
- **OTHER:** Quality-of-Life Assessment
- **RADIATION:** Radiation Therapy

## Key facts

- **NCT ID:** NCT04929041
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** SUSPENDED
- **Start date:** 2022-10-07
- **Primary completion:** 2030-12-12
- **Final completion:** 2030-12-12
- **Target enrollment:** 427 (ESTIMATED)
- **Why stopped:** End of Initial Phase of Multi-phase protocol
- **Last updated:** 2026-05-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04929041

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04929041, "Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative". Retrieved via MORVS 2026-10-17 from https://api.morvs.ai/clinical/NCT04929041. Licensed CC0.

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