Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

NCT04947254 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

200

Enrollment

OTHER

Sponsor class

Conditions

Prostate Carcinoma
Stage IIC Prostate Cancer AJCC v8
Stage III Prostate Cancer AJCC v8
Stage IIIA Prostate Cancer AJCC v8
Stage IIIB Prostate Cancer AJCC v8
Stage IIIC Prostate Cancer AJCC v8
Stage IVA Prostate Cancer AJCC v8

Interventions

DRUG: Abiraterone Acetate
DRUG: Antiandrogen Therapy
DRUG: Apalutamide
PROCEDURE: Biopsy
DRUG: Niraparib
DRUG: Prednisone
RADIATION: Radiation Therapy

Sponsor

M.D. Anderson Cancer Center