# Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease

> **NCT05022147** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **James Liao** · enrollment: 12 (estimated)

## Conditions studied

- Parkinson Disease
- Gait Disorders, Neurologic
- Disease Progression
- Subthalamic Nucleus
- Accidental Fall
- Deep Brain Stimulation

## Interventions

- **DEVICE:** High-Frequency-Only Stimulation
- **DEVICE:** Low-Frequency-Only Stimulation
- **DEVICE:** Alternating, 50 sec High-Frequency, 10 sec Low-Frequency Stimulation
- **DEVICE:** Alternating, 50 sec High-Frequency, 50 sec Low-Frequency Stimulation
- **DEVICE:** Alternating, 10 sec High-Frequency, 50 sec Low-Frequency Stimulation
- **DEVICE:** Alternating, 10 sec High-Frequency, 10 sec Low-Frequency Stimulation
- **DRUG:** OFF Dopaminergic Medication
- **DRUG:** ON Dopaminergic Medication

## Key facts

- **NCT ID:** NCT05022147
- **Lead sponsor:** James Liao
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-10-04
- **Primary completion:** 2024-11-15
- **Final completion:** 2026-05
- **Target enrollment:** 12 (ESTIMATED)
- **Last updated:** 2026-01-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05022147

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05022147, "Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease". Retrieved via MORVS 2026-10-05 from https://api.morvs.ai/clinical/NCT05022147. Licensed CC0.

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