T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers

NCT05035407 · clinicaltrials.gov ↗

PHASE1

Phase

TERMINATED

Status

36

Enrollment

NIH

Sponsor class

Stopped Site plans to become a site for a multicenter study of this therapy

Conditions

Kita-kyushu Lung Cancer Antigen 1, Human

Interventions

DRUG: IL-2 (Aldesleukin)
DRUG: Cyclophosphamide
BIOLOGICAL: KK-LC-1 TCR
DRUG: Fludarabine
DIAGNOSTIC_TEST: EKG
DIAGNOSTIC_TEST: CXR
DIAGNOSTIC_TEST: CT
DIAGNOSTIC_TEST: MRI
DIAGNOSTIC_TEST: PET
PROCEDURE: Biopsy
DRUG: Acetaminophen
DRUG: Ondansetron
DRUG: Meperidine
DRUG: Indomethacin
DRUG: Famotidine

Sponsor

National Cancer Institute (NCI)