Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
ACTIVE_NOT_RECRUITING
Status
Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Metastatic Head and Neck Squamous Cell Carcinoma
- Metastatic Hypopharyngeal Squamous Cell Carcinoma
- Metastatic Laryngeal Squamous Cell Carcinoma
- Metastatic Lip and Oral Cavity Carcinoma
- Metastatic Nasal Cavity Squamous Cell Carcinoma
- Metastatic Nasopharyngeal Squamous Cell Carcinoma
- Metastatic Pharyngeal Squamous Cell Carcinoma
- Metastatic Sinonasal Squamous Cell Carcinoma
- Recurrent Head and Neck Squamous Cell Carcinoma
- Recurrent Hypopharyngeal Squamous Cell Carcinoma
- Recurrent Laryngeal Squamous Cell Carcinoma
- Recurrent Lip and Oral Cavity Squamous Cell Carcinoma
- Recurrent Nasopharyngeal Squamous Cell Carcinoma
- Recurrent Pharyngeal Squamous Cell Carcinoma
- Recurrent Sinonasal Squamous Cell Carcinoma
- Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
- Stage IV Hypopharyngeal Carcinoma AJCC v8
- Stage IV Laryngeal Cancer AJCC v8
- Stage IV Lip and Oral Cavity Cancer AJCC v8
- Stage IV Nasopharyngeal Carcinoma AJCC v8
- Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
- Stage IV Sinonasal Cancer AJCC v8
Interventions
- BIOLOGICAL: Atezolizumab
- BIOLOGICAL: Bevacizumab
- PROCEDURE: Biospecimen Collection
- DRUG: Carboplatin
- BIOLOGICAL: Cetuximab
- DRUG: Cisplatin
- PROCEDURE: Computed Tomography
- DRUG: Docetaxel
- PROCEDURE: Echocardiography Test
- PROCEDURE: Magnetic Resonance Imaging
- PROCEDURE: Positron Emission Tomography
Sponsor
National Cancer Institute (NCI)