# Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury

> **NCT05204836** · PHASE1 · TERMINATED · sponsor: **University of Calgary** · enrollment: 4 (actual)

## Conditions studied

- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Injuries
- Osteo Arthritis Knee

## Interventions

- **DRUG:** Zoledronic Acid Injection
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT05204836
- **Lead sponsor:** University of Calgary
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2023-05-16
- **Primary completion:** 2025-07-03
- **Final completion:** 2025-07-03
- **Target enrollment:** 4 (ACTUAL)
- **Why stopped:** Recruitment stopped due to funding shortage. The scope of the original study increased beyond what had been budgeted in the grant that funded it, and follow-up funding attempts were not successful.
- **Last updated:** 2025-12-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05204836

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05204836, "Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury". Retrieved via MORVS 2026-10-13 from https://api.morvs.ai/clinical/NCT05204836. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*