Testing the Combination of APG-1252 (Pelcitoclax) and Cobimetinib in Recurrent Ovarian and Endometrial Cancers

NCT05691504 · clinicaltrials.gov ↗

PHASE1

Phase

ACTIVE_NOT_RECRUITING

Status

42

Enrollment

NIH

Sponsor class

Conditions

Advanced Endometrial Carcinoma
Metastatic Endometrial Carcinoma
Metastatic Fallopian Tube Carcinoma
Metastatic Platinum-Resistant Ovarian Carcinoma
Metastatic Primary Peritoneal Carcinoma
Recurrent Endometrial Carcinoma
Recurrent Fallopian Tube Carcinoma
Recurrent Platinum-Resistant Ovarian Carcinoma
Recurrent Primary Peritoneal Carcinoma
Stage III Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
Stage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
DRUG: Cobimetinib
PROCEDURE: Computed Tomography
PROCEDURE: Echocardiography Test
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Multigated Acquisition Scan
DRUG: Pelcitoclax

Sponsor

National Cancer Institute (NCI)