Hypoxia-driven Prostate Cancer Genomics (HYPROGEN)

Conditions

• Prostate Cancer
• Hypoxia

Interventions

• DRUG: Optional non-IMP pimonidazole
• DIAGNOSTIC_TEST: CT-guided Bone Biopsy
• DIAGNOSTIC_TEST: TRUS-guided Targeted Transperineal Prostate Biopsy
• PROCEDURE: Radical Prostatectomy
• DIAGNOSTIC_TEST: Whole-body MRI
• DIAGNOSTIC_TEST: Prostate MRI scans
• OTHER: Baseline bloods - for germline testing
• OTHER: Baseline bloods for CTCs and ct DNA taken at same time as baseline bloods in Arm 1
• OTHER: Post-pimonidazole bloods for CTCs and ctDNA

Sponsor

The Christie NHS Foundation Trust

Collaborators

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