Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

NCT05711615 · clinicaltrials.gov ↗

PHASE1

Phase

RECRUITING

Status

30

Enrollment

NIH

Sponsor class

Conditions

Metastatic Dedifferentiated Liposarcoma
Metastatic Leiomyosarcoma
Metastatic Myxofibrosarcoma
Metastatic Sarcoma
Metastatic Synovial Sarcoma
Metastatic Undifferentiated Pleomorphic Sarcoma
Unresectable Dedifferentiated Liposarcoma
Unresectable Leiomyosarcoma
Unresectable Myxofibrosarcoma
Unresectable Sarcoma
Unresectable Synovial Sarcoma
Unresectable Undifferentiated Pleomorphic Sarcoma

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
PROCEDURE: Echocardiography Test
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Multigated Acquisition Scan
DRUG: Pegylated Liposomal Doxorubicin Hydrochloride
DRUG: Peposertib

Sponsor

National Cancer Institute (NCI)