Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

NCT05896839 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

RECRUITING

Status

16

Enrollment

NIH

Sponsor class

Conditions

Clinical Stage III Cutaneous Melanoma AJCC v8
Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Clinical Stage IV Cutaneous Melanoma AJCC v8
Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
Metastatic Basal Cell Carcinoma
Metastatic Carcinoma in the Skin
Metastatic Melanoma
Metastatic Merkel Cell Carcinoma
Metastatic Skin Squamous Cell Carcinoma
Unresectable Basal Cell Carcinoma
Unresectable Melanoma
Unresectable Merkel Cell Carcinoma
Unresectable Skin Squamous Cell Carcinoma

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
BIOLOGICAL: Ipilimumab
PROCEDURE: Kidney Biopsy
PROCEDURE: Magnetic Resonance Imaging
BIOLOGICAL: Nivolumab
DRUG: Prednisone
DRUG: Sirolimus

Sponsor

National Cancer Institute (NCI)