Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

NCT05987241 · clinicaltrials.gov ↗

PHASE2,PHASE3

Phase

RECRUITING

Status

992

Enrollment

NIH

Sponsor class

Conditions

Muscle Invasive Bladder Urothelial Carcinoma
Muscle Invasive Renal Pelvis Urothelial Carcinoma
Muscle Invasive Ureter Urothelial Carcinoma
Muscle Invasive Urethral Urothelial Carcinoma
Stage II Bladder Urothelial Carcinoma AJCC v6 and v7
Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
Stage IV Bladder Urothelial Carcinoma AJCC v7

Interventions

PROCEDURE: Biospecimen Collection
OTHER: cfDNA or ctDNA Measurement
PROCEDURE: Computed Tomography
PROCEDURE: Cystoscopy
PROCEDURE: Magnetic Resonance Imaging
BIOLOGICAL: Nivolumab
OTHER: Questionnaire Administration
BIOLOGICAL: Relatlimab

Sponsor

National Cancer Institute (NCI)