Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

NCT06311214 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

500

Enrollment

NIH

Sponsor class

Conditions

Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
PROCEDURE: Echocardiography Test
OTHER: Electronic Health Record Review
DRUG: Enfortumab Vedotin
OTHER: Immunohistochemistry Staining Method
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Multigated Acquisition Scan
BIOLOGICAL: Sacituzumab Govitecan
BIOLOGICAL: Trastuzumab Deruxtecan

Sponsor

National Cancer Institute (NCI)