Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

NCT06484062 · clinicaltrials.gov ↗

PHASE1

Phase

RECRUITING

Status

54

Enrollment

NIH

Sponsor class

Conditions

Acute Myeloid Leukemia
Myelodysplastic Syndrome
Myelodysplastic Syndrome/Acute Myeloid Leukemia
Recurrent Acute Myeloid Leukemia
Recurrent Myelodysplastic Syndrome
Recurrent Myelodysplastic Syndrome/Acute Myeloid Leukemia
Refractory Acute Myeloid Leukemia
Refractory Myelodysplastic Syndrome
Refractory Myelodysplastic Syndrome/Acute Myeloid Leukemia

Interventions

PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration
DRUG: Cirtuvivint
DRUG: Decitabine and Cedazuridine
PROCEDURE: Echocardiography Test
PROCEDURE: Multigated Acquisition Scan

Sponsor

National Cancer Institute (NCI)