Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau

Conditions

• Alzheimer Disease, Early Onset

Interventions

• DEVICE: Neuronavigation-guided single-element focused ultrasound transducer
• DRUG: Lumason
• OTHER: Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents
• RADIATION: Positron Emission Tomography (PET)
• DRUG: Amyvid
• DRUG: MK-6240
• DRUG: Dotarem
• DIAGNOSTIC_TEST: Blood draw
• DEVICE: UR5e
• DIAGNOSTIC_TEST: Urine test

Sponsor

Columbia University