A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

NCT06661915 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

62

Enrollment

NIH

Sponsor class

Conditions

Accelerated Phase Myeloproliferative Neoplasm
Blast Phase Myeloproliferative Neoplasm
Essential Thrombocythemia
Myelodysplastic/Myeloproliferative Neoplasm
Myeloproliferative Neoplasm, Not Otherwise Specified
Polycythemia Vera
Primary Myelofibrosis
Secondary Myelofibrosis

Interventions

PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy
DRUG: Decitabine and Cedazuridine
DRUG: Iadademstat

Sponsor

National Cancer Institute (NCI)