Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

NCT06811116 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

RECRUITING

Status

92

Enrollment

NIH

Sponsor class

Conditions

Advanced Hepatocellular Carcinoma
Metastatic Hepatocellular Carcinoma
Stage III Hepatocellular Carcinoma AJCC v8
Stage IV Hepatocellular Carcinoma AJCC v8

Interventions

PROCEDURE: Biospecimen Collection
DRUG: Cabozantinib S-malate
PROCEDURE: Imaging Procedure
DRUG: Sapanisertib

Sponsor

National Cancer Institute (NCI)