# Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction

> **NCT06980623** · — · ACTIVE_NOT_RECRUITING · sponsor: **Brigham and Women's Hospital** · enrollment: 26000 (estimated)

## Conditions studied

- Type 2 Diabetes
- Heart Failure

## Interventions

- **DRUG:** Tirzepatide
- **DRUG:** Semaglutide

## Key facts

- **NCT ID:** NCT06980623
- **Lead sponsor:** Brigham and Women's Hospital
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2025-01-01
- **Primary completion:** 2025-11-30
- **Final completion:** 2026-10-01
- **Target enrollment:** 26000 (ESTIMATED)
- **Last updated:** 2026-05-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06980623

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06980623, "Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT06980623. Licensed CC0.

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