Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

NCT07391774 · clinicaltrials.gov ↗

PHASE3

Phase

NOT_YET_RECRUITING

Status

1978

Enrollment

NIH

Sponsor class

Conditions

Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage IIIA Breast Cancer AJCC v8
Anatomic Stage IIIC Breast Cancer AJCC v8
Estrogen Receptor-Positive Breast Carcinoma
HER2-Negative Breast Carcinoma

Interventions

DRUG: Anastrozole
PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Scan
DRUG: Chemotherapy
PROCEDURE: Computed Tomography
DRUG: Exemestane
DRUG: Letrozole
PROCEDURE: Oncotype DX Breast Cancer Assay
PROCEDURE: Positron Emission Tomography
DRUG: Ribociclib Succinate

Sponsor

National Cancer Institute (NCI)