SHAPE-ENDO: Multimodal Pre-Surgical Optimization in Patients With Obesity and Early-Stage Endometrial Cancer (Phase 1)

NCT07462663 · clinicaltrials.gov ↗

PHASE4

Phase

NOT_YET_RECRUITING

Status

82

Enrollment

OTHER

Sponsor class

Conditions

Endometrial Cancer
Endometrial Cancer Stage I
Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I
Atypical Endometrial Hyperplasia
Endometrial Intraepithelial Neoplasia
Obesity & Overweight
BMI>40
Obesity
Obesity Grade III

Interventions

DRUG: GLP-1 Receptor Agonist
DEVICE: Levonorgestrel IUD (Lng-IUD)
DRUG: Oral Progestins
BEHAVIORAL: Dietetic-Nutritional intervention
BEHAVIORAL: Structured Exercise and Prehabilitation Program
PROCEDURE: Endometrial Biopsy With or Without Hysteroscopy
PROCEDURE: Radiologic Surveillance (MRI and Transvaginal Ultrasound)

Sponsor

Hospital Universitari de Bellvitge

Collaborators

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