Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as Conditioning for Allogeneic Peripheral Blood Stem Cell Hematopoietic Cell Transplant in Older Patients With Refractory and Relapsed Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome
Conditions
- Acute Myeloid Leukemia With Complex Karyotype
- Myelodysplastic Chronic Myelomonocytic Leukemia
- Myelodysplastic Syndrome
- Recurrent Acute Myeloid Leukemia
- Recurrent Myelodysplastic Chronic Myelomonocytic Leukemia
- Recurrent Myelodysplastic Syndrome
- Recurrent Secondary Acute Myeloid Leukemia
- Refractory Acute Myeloid Leukemia
- Refractory Myelodysplastic Chronic Myelomonocytic Leukemia
- Refractory Myelodysplastic Syndrome
- Refractory Secondary Acute Myeloid Leukemia
Interventions
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Bone Marrow Biopsy
- PROCEDURE: Computed Tomography
- PROCEDURE: Echocardiography Test
- DRUG: Fludarabine Phosphate
- DRUG: Melphalan
- PROCEDURE: Multigated Acquisition Scan
- BIOLOGICAL: Palifermin
- PROCEDURE: Peripheral Blood Stem Cell Transplantation
- OTHER: Questionnaire Administration
- DRUG: Sirolimus
- DRUG: Tacrolimus
- RADIATION: Total Marrow and Lymphoid Irradiation
Sponsor
City of Hope Medical Center
Collaborators