# Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment

> **NCT07636564** · PHASE2 · NOT_YET_RECRUITING · sponsor: **SWOG Cancer Research Network** · enrollment: 90 (estimated)

## Conditions studied

- Acute Leukemia of Ambiguous Lineage
- B Acute Lymphoblastic Leukemia
- B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
- T Acute Lymphoblastic Leukemia

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **BIOLOGICAL:** Blinatumomab
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **DRUG:** Calaspargase Pegol
- **PROCEDURE:** Chest Radiography
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **DRUG:** Cytarabine
- **DRUG:** Daunorubicin Hydrochloride
- **DRUG:** Dexamethasone
- **DRUG:** Doxorubicin
- **PROCEDURE:** Echocardiography Test
- **DRUG:** Leucovorin Calcium
- **DRUG:** Mercaptopurine
- **DRUG:** Methotrexate
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Positron Emission Tomography
- **DRUG:** Revumenib
- **DRUG:** Thioguanine

## Key facts

- **NCT ID:** NCT07636564
- **Lead sponsor:** SWOG Cancer Research Network
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-10-14
- **Primary completion:** 2031-04-16
- **Final completion:** 2032-04-16
- **Target enrollment:** 90 (ESTIMATED)
- **Last updated:** 2026-06-09

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07636564

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07636564, "Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07636564. Licensed CC0.

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