# Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery

> **NCT07644065** · NA · COMPLETED · sponsor: **Plovdiv Medical University** · enrollment: 40 (actual)

## Conditions studied

- Impacted Third Molar
- Postoperative Pain
- Neuroinflammation
- Anxiety

## Interventions

- **DRUG:** Placebo
- **DRUG:** Ibuprofen
- **DRUG:** Ibuprofen + Gabapentin

## Key facts

- **NCT ID:** NCT07644065
- **Lead sponsor:** Plovdiv Medical University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-10-16
- **Primary completion:** 2020-05-17
- **Final completion:** 2020-09-30
- **Target enrollment:** 40 (ACTUAL)
- **Last updated:** 2026-10-07

## Collaborators

- [object Object]
- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07644065

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07644065, "Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07644065. Licensed CC0.

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