# Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

> **NCT07649291** · PHASE2 · NOT_YET_RECRUITING · sponsor: **VA Office of Research and Development** · enrollment: 102 (estimated)

## Conditions studied

- Knee Osteoarthritis
- Pain
- Depression

## Interventions

- **BEHAVIORAL:** Exercise
- **DRUG:** Duloxetine
- **DRUG:** Placebo
- **BEHAVIORAL:** PT referral

## Key facts

- **NCT ID:** NCT07649291
- **Lead sponsor:** VA Office of Research and Development
- **Sponsor class:** FED
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2027-03-01
- **Primary completion:** 2031-09-01
- **Final completion:** 2032-09-01
- **Target enrollment:** 102 (ESTIMATED)
- **Last updated:** 2026-06-16

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07649291

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07649291, "Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)". Retrieved via MORVS 2026-10-21 from https://api.morvs.ai/clinical/NCT07649291. Licensed CC0.

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