# AMC 120, Glofitamab Plus Chemoimmunotherapy in Newly Diagnosed HIV-Associated Large B-Cell Lymphoma (The "Glofit-RCHOP Study")

> **NCT07649304** · PHASE1 · NOT_YET_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 15 (estimated)

## Conditions studied

- AIDS-Related Diffuse Large B-cell Lymphoma
- Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- High Grade B-Cell Lymphoma With MYC and BCL2 Rearrangements
- High Grade B-Cell Lymphoma, Not Otherwise Specified
- Lugano Classification Stage II Adult Non-Hodgkin Lymphoma AJCC v8
- Lugano Classification Stage III Adult Non-Hodgkin Lymphoma AJCC v8
- Lugano Classification Stage IV Adult Non-Hodgkin Lymphoma AJCC v8
- Plasmablastic Lymphoma
- Primary Effusion Lymphoma

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **DRUG:** Doxorubicin Hydrochloride
- **PROCEDURE:** Echocardiography Test
- **BIOLOGICAL:** Glofitamab
- **PROCEDURE:** Positron Emission Tomography
- **DRUG:** Prednisone
- **OTHER:** Questionnaire Administration
- **BIOLOGICAL:** Rituximab
- **DRUG:** Vincristine Sulfate

## Key facts

- **NCT ID:** NCT07649304
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-10-09
- **Primary completion:** 2028-04-30
- **Final completion:** 2028-04-30
- **Target enrollment:** 15 (ESTIMATED)
- **Last updated:** 2026-08-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07649304

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07649304, "AMC 120, Glofitamab Plus Chemoimmunotherapy in Newly Diagnosed HIV-Associated Large B-Cell Lymphoma (The "Glofit-RCHOP Study")". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07649304. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*