Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE Trial

NCT07650240 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

202

Enrollment

OTHER

Sponsor class

Conditions

Recurrent Prostate Adenocarcinoma
Stage IVB Prostate Cancer AJCC v8
Castration-Sensitive Prostate Cancer
Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
Prostate Cancer
Prostate Adenocarcinoma
Adenocarcinoma of the Prostate
Localized Prostate Carcinoma
Metastatic Prostate Cancer
Metastatic Prostate Adenocarcinoma
Advanced Prostate Cancer
Advanced Prostate Adenocarcinoma

Interventions

DRUG: Abiraterone Acetate
PROCEDURE: Biospecimen Collection
DRUG: Leuprolide Acetate
DRUG: Lutetium Lu 177 Vipivotide Tetraxetan
DRUG: Prednisone
PROCEDURE: PSMA PET-CT Scan
OTHER: Quality-of-Life Assessment
PROCEDURE: Single Photon Emission Computed Tomography

Sponsor

Mayo Clinic