# Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation

> **NCT07654179** · NA · RECRUITING · sponsor: **Riphah International University** · enrollment: 200 (estimated)

## Conditions studied

- Depression
- Depressive Disorder
- Overweight or Obesity
- Depressive Symptoms

## Interventions

- **DRUG:** Metformin
- **DRUG:** Antidepressant Therapy

## Key facts

- **NCT ID:** NCT07654179
- **Lead sponsor:** Riphah International University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-06-17
- **Primary completion:** 2027-06-11
- **Final completion:** 2027-06-11
- **Target enrollment:** 200 (ESTIMATED)
- **Last updated:** 2026-08-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07654179

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07654179, "Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation". Retrieved via MORVS 2026-10-21 from https://api.morvs.ai/clinical/NCT07654179. Licensed CC0.

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